Rebecca Harris
The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography
Harris, Rebecca; Card, Timothy R.; Delahooke, Toby; Aithal, Guruprasad P.; Guha, Indra Neil
Authors
Dr TIM CARD tim.card@nottingham.ac.uk
CLINICAL ASSOCIATE PROFESSOR
Toby Delahooke
Professor GURUPRASAD AITHAL Guru.Aithal@nottingham.ac.uk
PROFESSOR OF HEPATOLOGY
Professor NEIL GUHA neil.guha@nottingham.ac.uk
PROFESSOR OF HEPATOLOGY
Abstract
Background: Transient elastography is a non-invasive tool which can stratify patients at risk of chronic liver disease. However, a raised body mass index has been independently associated with a failed or unreliable examination.
Objective: The purpose of this study was to analyse the performance of two probes (M/XL) on a portable transient elastography device within an obese community population.
Method: The method involved a prospective study with recruitment from a primary care practice. Patients identified with a risk factor for chronic liver disease were invited to a community-based risk stratification pathway for transient elastography readings with both probes. A threshold of ≥8.0 kPa defined elevated liver stiffness.
Results: A total of 477 patients attended the pathway. Of the patients, 21% had no valid measurements with the M probe. There was a significant difference between the probes in the proportion achieving ≥10 valid readings (M versus XL probe: 66.2% versus 90.2%; p ≤ 0.001) and in their reliability (M versus XL probe: 77.4% versus 98.5%; p = 0.028). Unreliable readings with the M probe increased as the body mass index increased. The XL probe re-stratified 5.2% of patients to have a normal reading.
Conclusion: The XL probe on a portable device significantly improves the applicability of transient elastography within a community-based risk stratification pathway.
Citation
Harris, R., Card, T. R., Delahooke, T., Aithal, G. P., & Guha, I. N. (2018). The XL probe: a luxury or a necessity? risk stratification in an obese community cohort using transient elastography. United European Gastroenterology Journal, 6(9), 1372-1379. https://doi.org/10.1177/2050640618772944
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 31, 2018 |
Online Publication Date | Apr 18, 2018 |
Publication Date | Apr 18, 2018 |
Deposit Date | Sep 19, 2018 |
Publicly Available Date | Sep 19, 2018 |
Journal | United European Gastroenterology Journal |
Print ISSN | 2050-6406 |
Electronic ISSN | 2050-6414 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 9 |
Pages | 1372-1379 |
DOI | https://doi.org/10.1177/2050640618772944 |
Public URL | https://nottingham-repository.worktribe.com/output/1090689 |
Publisher URL | http://journals.sagepub.com/doi/10.1177/2050640618772944 |
Additional Information | Copyright © 2018 by United European Gastroenterology |
Contract Date | Sep 19, 2018 |
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